Synthesis of -Lactam Fused Enediynes by Intramolecular Kinugasa Reaction: Comparison of Reactivity with Monocyclic Analogues
نویسندگان
چکیده
-lactam fused enediynes have been successfully synthesized by intramolecular Kinugasa reaction in moderate yields. DSC studies indicated significant influence of the -lactam ring upon the reactivity of enediynes. None of the -lactam fused enediynes (under ring opening conditions) as well as the 11-membered monocyclic enediyne as the tosylate salt showed any cleavage of plasmid DNA. Interestingly, the 10-membered enediyne as the tosylate salt cleaved both single and double strands of plasmid DNA at micromolar concentration.
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